Book Review: ‘Breakthrough’ by William Pao

Book Title: Breakthrough: The Quest for Life-Changing Medicines
Author: William Pao
Publisher: Oneworld Publications
Number of Pages: 352
ISBN: 978-1836430605
Date Published: Oct. 30, 2024
Price: INR 333

Book Review

In “Breakthrough: The Quest for Life-Changing Medicines“, William Pao shares fascinating stories about how some of the most important medicines were discovered. Drawing from his experience as a doctor and pharmaceutical expert, Pao takes readers behind the scenes to show the hard work, creativity, and a bit of luck that go into developing treatments for diseases like cancer, sickle cell anemia, AIDS, and COVID-19. Instead of focusing on his personal story or defending the pharmaceutical industry, Pao shines a light on the people and ideas driving medical breakthroughs.

The book starts by explaining basic concepts like DNA and mRNA in simple terms, making it easy to follow even if you’re not a scientist. Each chapter then tells the story of how a particular medicine was created, from accidental discoveries like paracetamol to clever problem-solving, like turning a Coke machine into a research tool. These examples show how persistence and imagination are key to finding new treatments.

One of the most exciting parts is the story of how scientists quickly developed COVID-19 antivirals. Even while working from home during the pandemic, researchers collaborated online to refine compounds and create life-saving drugs in record time. Pao also highlights the personal motivations of scientists, like a doctor inspired by a patient’s struggle or a researcher driven by a childhood tragedy, which add a heartfelt touch to the scientific achievements. This section of the book is likely to remind Indian readers of the crucial role India played in producing the first COVID-19 vaccine.

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Finally, books like “Breakthrough” celebrate the dedication of scientists who never give up, even when progress is slow or uncertain. Their work has saved countless lives, and this book helps us appreciate the effort behind the medicines we often take for granted. It’s an inspiring and easy-to-read look at how curiosity and determination can change the world.

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